Posted by You’ve probably heard that 7-OH, Oxonol, and Pseudo can each give you a mood lift. But that’s usually secondary to their pain-relieving effects, energy from 7-OH, smooth clarity from Oxonol, and heavy grounding from Pseudo. What if you considered each of them on their own for their emotion-boosting properties?
Although scientific research doesn’t really exist for this subject, we can still look at their effects on neurochemistry as well as the general subjective reports people make from each kratom botanical. That way, you can decide which type of mood boost you prefer.
Let’s get into it.
What Advantages Do They Have Over Kratom or Mushrooms?
7-OH and Pseudo exist naturally as metabolites of kratom. Oxonol is an enhanced kratom alkaloid blend. All three of these kratom derivatives are more potent than kratom and they can also be ranked in potency relative to each other (Pseudo, Oxonol, and 7-OH).
With regard to their effects in comparison to mushrooms (synthetic psychedelic mushrooms), they differ on energy and mood. Mushrooms are for microdosing for focus and introspection and don’t relieve pain, but 7-OH, Oxonol, and Pseudo do. The latter three botanicals work on opioid receptors; they don’t just cause feel-good neurotransmitters to release. That means they have a different approach to emotional uplift, a unique euphoria that I can describe the best way I know how, but ultimately is about experiencing for yourself.
See also: Boosting Your Mood with Kratom, Kratom and Kava, or Mushrooms
What’s the Point of a Mood Lift?
Feeling relatively content in day-to-day life is a big deal because it makes for a good – or rather, better – quality of life. A positive mood encourages motivation, productivity, better perception, and better people-bonding. It also helps with memory and energy and supports the immune system. However, there are different ways to get to that point. It’s easier or harder depending on one’s lifestyle, so when people need a little help, that’s where botanicals can come in to brighten their day or make a memorable night.
Botanicals are a way to get multiple effects at once that includes a mood lift. Each does so uniquely, so let’s explore what that means science-wise and how they make people feel emotionally.
7-OH for Sedating Euphoria
Here is a mixed agonist/antagonist opioid receptor profile. 7-OH is a partial agonist at mu-opioid receptors and a competitive antagonist at delta- and kappa-opioid receptors. It lasts all day and is a solid alcohol alternative. However, it does carry the risk of tolerance, dependence, and side effects like respiratory depression, drowsiness, and nausea.
- Pain relief for moderate to severe pain
- Takes effect within 10 minutes for chewable tablets, even sooner for shots
- Pain relief, euphoria, sociability, calm and clear-headedness
- Lasts for 6 to 8 hours
Oxonol for Smooth, Light Calm and Euphoria
Oxonol is a proprietary 7-OH alternative with the most similar equivalent probably being MGM15. The difference is that Oxonol is an enhanced kratom alkaloid blend instead of being a single alkaloid profile, but way more potent at mu-opioid receptors than kratom, which focuses on the alkaloid mitragynine. Oxonol avoids much of the risk of adverse effects of 7-OH, but may induce a dysphoric-like detachment, since it partially binds to mu, delta, and kappa-opioid receptors in that order. It’s also more widely legal where 7-OH is often banned.
- Mild to moderate pain relief
- Milder euphoria and analgesia that’s not overwhelming
- Usually lasts for 6 hours (chewable tablets)
- No crash after peak
Pseudo for Heavy, Grounding Euphoria
Another kratom alkaloid, Pseudo stands for pseudoindoxyl mitragynine. It’s also a metabolite of mitragynine (kratom) and a rearrangement of 7-hydroxymitragynine that avoids much of its adverse effects. With just a few tweaks, it can serve as a stronger pain relief for severe or chronic pain sufferers and lasts longer than Oxonol. Pseudo is a MOR agonist and competitive DOR antagonist, but with more MOR affinity than kratom, 7-OH, and Oxonol.
- Severe pain relief without putting you to sleep
- Strongest analgesia and euphoria
- Lasts for up to 8 hours (chewable tablets)
- Dosing is as easy as one-and-done
Comparison Table
| Feature | 7-OH | Oxonol | Pseudo |
| Mood lift effects | Euphoric, calm, clear, pain relief; often requires only 1 dose throughout the day | Gentle pain relief to reduce discomfort and euphoria; usually needs additional dosing throughout the day | Strongest body-euphoria and pain relief; one-and-done dosing |
| Opioid receptor activity | Partial MOR agonist/competitive DOR and KOR antagonist | MOR, DOR, and KOR partial agonist | Partial MOR agonist and competitive DOR antagonist |
| Okay for uncontrolled environments? | Yes, at low doses (alcohol alternative) | Yes, at low to moderate doses | Yes, if you’re an experienced user |
Choosing a Mood-Lifting Botanical
Now that you’ve got a feel for the unique mood-lifting effects of 7-OH, Oxonol, and Pseudo, you can more easily select the product that best suits your lifestyle and emotional goals. Whether you woke up on the wrong side of the bed, want to take the edge off, or are looking for a social botanical that won’t intoxicate you the way alcohol does, consider Real Botanicals. With the same precision-focused manufacturing, quality control, and targeted or broad-spectrum effects for every product, you can’t go wrong with the simple, premium formulations they have to offer.
See “7-Hydroxymitragynine Beginner Guide: Effects, Legality & Safety Tips” and “Getting Up the Next Day: Does Kratom or 7-OH Make You Crash?“