Pseudoindoxyl is one of two alternatives to 7-OH, the other being Oxonol. The analgesic opioid can serve as pain relief, a mood booster, and anxiety reducer.
Food is even more important because it keeps you going, and if you’re functioning at a high level, you need fuel for energy. Many people need to eat 2 to 3 meals a day, or sometimes one large meal. Sometimes, adding a new substance into your lifestyle can change your eating habits.
Scheduling meals around supplements matters, too. Pseudo may affect what you eat, how much you eat, or how you keep up with daily meals. Let’s dive in.
Opioid Effects on Appetite
The effects of opioids on appetite are a mixture. On the one hand, they can cause nausea and constipation, and that’s very off-putting for eating and even feeling hungry. So it can suppress appetite as well as pain signals. If they cause drowsiness, then the user will be too busy sleeping to eat. But when opioids wear off, appetite can come back with a vengeance.
For some people, opioids may stimulate their appetite instead. For them, they don’t feel full as easily as they used to, leading to eating more food than usual.
Eating Habits on Opioids in General
Depending on the type of opioid, dosage, and frequency, the user may experience a change in their brain’s reward pathways. Instead of the usual foods being appetizing, they aren’t any more. The user may seek out high-sugar, high-calorie, and high-fat foods to compensate for the lack of pleasure they feel from eating their normal meals.
Some people may experience a lack of interest in food and develop strange eating habits. They can easily experience malnourishment from their insufficient diet, especially if they focus on opioid use to develop tolerance and addiction.
What About Cravings?
When we talk about opioids causing cravings, we don’t usually mean food. Instead, we’re referring to the development of addiction where the user wants to take more when the effects wear off, experiences withdrawal symptoms when not taking it, and wants to feel the euphoric “high” all the time. But this type of craving does interfere with craving food, because the substance becomes more important.
If the user does experience food cravings, though, they will tend to want to eat unhealthy “junk” food. We’re talking about sweets, fried foods, and starches. It’s a way of extending the sensations of euphoria and pleasure – it’s also a result of finding normal food no longer appealing or appetizing.
Why Pseudo Is Different
While opiates are all natural derivatives from the opium poppy plant, opioids include natural, semi-synthetic and synthetic derivatives of opioid compounds. Many involve the opium poppy plant’s opiates in some form, but not all.
Pseudo is one example of an opioid that has nothing to do with opium poppy. Instead, it’s an altering of a specific alkaloid from kratom – mitragynine pseudoindoxyl – that has undergone oxidation. It’s also a metabolite of the minor alkaloid in kratom known as 7-hydroxymitragynine when someone takes kratom and it enters the bloodstream.
What Pseudo Does to Hunger
To understand how Pseudo affects how you feel hunger pangs, let’s review what it does to neurotransmitters. Pseudo activates mu-opioid receptors and fulfills but binds to and does not activate delta-opioid receptors. Mu-opioid receptors are important for things such as pain relief, the main appeal of 7-OH and its alternatives, including Pseudo.
They also trigger sensations of reward and pleasure. Some users experience nausea while taking opioids, such as Pseudo, so that side effect decreases appetite. But with the mu-opioid receptor activation, the user will seek out more pleasurable-tasting foods – not necessarily unhealthy foods.
On the other hand, Pseudo doesn’t carry the same risk of tolerance, withdrawal symptoms, and addiction that 7-OH does. So while users may experience appetite changes while taking Pseudo, fortunately, the changes only last as long as the Pseudo lasts.
That doesn’t have to be a bad thing. Since delta-opioid receptor antagonists are potentially useful for therapeutic purposes in mood disorders such as depression and anxiety, Pseudo is promising. People with depression or anxiety may eat more or less to try to feel better. But with Pseudo, they will feel emotionally stable.
The Verdict: Pseudo doesn’t have the same sharp onset and heavy drowsy feeling 7-OH can cause, although it is more sedating. It feels more grounding and makes the user more aware of their body. Emotional effects are also more stable, so users might not experience a big change in how they experience hunger or in their appetite and the foods they seek out.
Look for the Best Pseudo No Longer
Pseudo is one of the best 7-OH alternatives that exists. Because of its smoother, clearer, and grounding effects, and fewer side effects than 7-OH, it is appealing to people seeking potent pain relief and a mood lift. It also lasts longer, making it so that users don’t need to take as much for all-day wellness.
When you’re ready to try the best Pseudo, consider Real Botanicals. The chewable tablets come in Wintergreen flavor and the mitragynine pseudoindoxyl alkaloid undergoes the company’s proprietary ChromaPure clean extraction process. They split into quarters, giving you full control with the minimum dosage you need for powerful results.
Check out “How Does Oxonol Affect Hunger?“

