Posted by MIT is the abbreviation for mitragynine, the most plentiful alkaloid in kratom leaves. Oxonol is an enhanced kratom alkaloid blend by Real Botanicals that includes mitragynine. They are the farthest apart for comparing single and multiple kratom alkaloid products.
With the upcoming federal ban on concentrated kratom alkaloid products, MIT and other kratom products are safe. This is an important factor when deciding on the kratom product you want in the future.
Where They Come From
The patented enhanced kratom alkaloid blend by Real Botanicals, Oxonol, focuses on three main compounds for nuanced, broad-spectrum effects:
- Mitragynine, abbreviated as MIT. This predominant alkaloid in kratom leaves makes up ⅔ of the total alkaloid content in full-spectrum kratom or can be a single alkaloid isolate. Smooth balance, energy, and focus with mood enhancement are its effects.
- 7-hydroxymitragynine, or 7-OH for short, is a minor alkaloid in kratom leaves that makes up maybe 2% of the total alkaloid content. For this reason, it cannot come direct as a single alkaloid isolate from kratom but as a chemical conversion from mitragynine. Pain relief and mood elevation are its effects.
- MGM15 is the branding name for DH-7OH-MIT or dihydro-7-hydroxymitragynine. It gives consistency, smoothness, long-lasting effects that don’t sedate at higher doses, unlike 7-OH.
MIT is the concentrated extract of mitragynine. People seek it out as opposed to full-spectrum kratom when they want a targeted, single-alkaloid profile with a narrow range of effects. Unlike Oxonol, it is dose-dependent, with stimulation at low doses and sedation at high doses.
Opioid Receptor Action and Effects
Seeing as Oxonol is an enhanced alkaloid blend, it has several opioid receptor actions going on. All alkaloids within it bind to mu-opioid receptors to varying degrees, with mitragynine the least, followed by 7-OH and MGM15. Oxonol blocks kappa receptor activation (relieves depression and anxiety) but has both activating and blocking actions on delta opioid receptors, leading to a reduction of side effects like respiratory depression. Choose Oxonol when you want gentle pain relief with mental clarity.
MIT is a partial agonist at the mu-opioid receptor. Its benefits are mood enhancement, energy, and focus, as well as some measure of pain relief that can range from mild to moderate. It is a dose-dependent alkaloid that acts as a nootropic at low doses and is stimulating, or opioid-like and sedating at high doses. Choose MIT if you want a caffeine-free start to your day, a pick-me-up, or clear your head after work and help you recover from exercise.
Scheduling Protocol, Side Effects and Risks
No matter whether you’re thinking about trying Oxonol or MIT, you should be planning for a scheduling protocol. It’s a cycle of on and off days, usually 5 days on, 2 days off, or sometimes 3 days on, 1 day off. That’s for users who take either on a regular basis as opposed to the occasional blue moon, and it helps to avoid tolerance development and dependence. Click here to read about a scheduling protocol for Oxonol, and here for kratom (MIT).
Perhaps the biggest difference between the side effects and risks of Oxonol vs. MIT is the level. Those of Oxonol are stronger than MIT, so take that into consideration if you’re deciding between them or another kratom alkaloid.
Comparison Table
| MIT | Oxonol | |
| Targeted or broad-spectrum alkaloid profile? | Targeted (strong onset, peak, narrow range of effects) | Broad-spectrum (gradual onset, nuanced effects, more complex) |
| Effects | Energy, focus (low doses) or sedation (high doses), mild to moderate pain relief | Smooth, light, balanced, mental clarity, pain relief |
| Side effects | Jitteriness, insomnia, GI effects, sedation at high doses | Light-headedness |
| Strength with MIT as baseline | Baseline | 7-OH alternative not as potent but much more than kratom |
| Legal? | Yes | Not with upcoming federal ban |
| Alternative? | Yes – High-MIT Acend | Yes – kratom products |
In Light of the Temporary Federal Ban in August
There’s still time to enjoy and stock up on Oxonol by Real Botanicals with their blowout sale on concentrated kratom alkaloid products. The ban includes Pseudo and 7-OH, making three very different options, one of which (Oxonol) is totally unique and exclusive.
What all of Real Botanicals’ products have in common is their approach to processing and formulation. They’ve also patented an advanced technology for extraction and purification, ChromaPure. Their ingredients include pharmaceutical-grade microcrystalline and no sugar or gluten, all vegan to avoid allergies and sensitivities. When it comes to kratom, they source from the full alkaloid spectrum of the whole leaf.
To that end, consider alternatives like High-MIT Attitude Adjustment Acend tablets or Super Kratom kratom capsules in three strengths. Both are full-spectrum, with Super Kratom containing the natural variability and Acend the precise proportions of alkaloids. Eventually, Oxonol will reappear with a new formula for continued legal compliance.
One Vendor That Goes with the Flow
New product releases are in the making with Real Botanicals. Because the temporary ban is just a challenge, not the end. It’s a good thing that their product line, although small, has the diversity it needs to continue to offer premium, legally-compliant botanicals. Part of the reason is being manufacturer-direct, so they’re not beholden to anyone else for research and development and the entire process from sourcing to the final product.
Recommended reading: “MGM15 vs. Oxonol” or “Can You Switch from Kratom to 7-OH and Vice-Versa?”