Posted by Here’s a comparison you’ve never heard of until now: MGM15 and Oxonol. While you’ve probably heard of MGM15 by way of 7-OH, you may not have known about Oxonol unless you came across Real Botanicals.
MGM15 is the name for dihydro-7-hydroxymitragynine, and as you suspected, it’s a lab-modified semi-synthetic derivative of 7-OH. Oxonol is Real Botanicals’ patented enhanced kratom alkaloid blend that includes 7-OH, MGM15, and mitragynine.
That just scratches the surface. Here’s a deeper look at their pharmacology and effects.
Backgrounds
The laboratory is where all the magic happens. Neither formula is attainable directly from the kratom leaf, but at some point, the alkaloids underwent extraction.
MGM15 is created through chemical modification of mitragynine, which metabolizes into 7-hydroxymitragynine. You wouldn’t guess from its shorthand name, but its chemical name is dihydro-7-hydroxymitragynine. The process makes it hydrogenated to create saturated, bioactive compounds and complex molecules 7-OH doesn’t have. You can find MGM15 in the form of powders and tablets.
Oxonol comes together with various concentrated kratom alkaloids that are beneficial for offering a broad-spectrum alkaloid profile in the form of chewable tablets:
- MIT is shorthand for the primary alkaloid in kratom, mitragynine. It’s used as the baseline for kratom alkaloids. In a blend, it offers smoothness, energy, and focus – the mental clarity people report from Oxonol.
- 7-OH stands for 7-hydroxymitragynine, a minor kratom alkaloid present in tiny amounts. In a concentrated extract, it’s a potent analgesic with mood enhancement.
- MGM15 comes in to bring balance and less sedation at higher amounts than 7-OH.
Opioid Receptor Action and Effects
The actions of concentrated kratom alkaloids on the three main opioid receptors contribute to their unique effects. They can be an agonist (bind to) or antagonist (block the activation of) depending on the receptor.
MGM15 is said to be a lot like 7-OH but more potent, faster-acting, and longer-lasting, with increased mu-opioid receptor affinity. It has a high affinity (binds strongly) to mu- and delta-opioid receptors. This makes it effective for both acute and chronic pain.
From the combination of concentrated kratom alkaloids in Oxonol, their opioid receptor action is as follows: 7-OH (MOR agonist and DOR and KOR antagonist), MOR and DOR agonist (MGM15), and mildly MOR agonist (MIT). The DOR antagonism of 7-OH alleviates dysphoria, depression, and anxiety, while the KOR antagonist reduces the risk of respiratory depression.
Scheduling Protocol, Side Effects and Risks
While it’s tempting to create your own scheduling protocol willy-nilly, it’s not sustainable. A scheduling or cycling protocol is meant to give the offer a time period when they take the kratom product and when they skip it. Its purpose is to reduce developing tolerance and dependence with withdrawal symptoms that make it difficult to stop.
For more information on scheduling protocol for 7-OH, click here. It applies to MGM15 and Oxonol as well.
The side effects and risks of MGM15 are more severe than Oxonol. Side effects include respiratory depression, drowsiness, and nausea. As with any opioid-like botanical, excessively high doses run the risk of Serotonin Syndrome.
In terms of side effects and risks, I would place Oxonol in a lower (better) ranking over MGM15. It’s not hard to see why: Oxonol is softened by the inclusion of mitragynine, the mildest-binding to mu-opioid receptors. At low doses, it acts like a nootropic for energy and focus, and offsets any potential drowsiness.
Comparison Table
| MGM15 | Oxonol | |
| Targeted or broad-spectrum alkaloid profile? | Targeted (fast-acting, high peak, narrow range of effects) | Broad-spectrum (gradual onset, nuanced effects, more complex) |
| Effects | Sedation, acute and chronic pain relief, mood enhancement | Smooth, light, balanced, mental clarity, pain relief |
| Side effects | Nausea, constipation, loss of appetite, dizziness, insomnia or drowsiness | Light-headedness or dysphoria |
| Strength with MIT as baseline | 3.5 times potent than 7-OH and several times more than kratom | 7-OH alternative not as potent but much more than kratom |
| Legal? | Not with upcoming federal ban | Not with upcoming federal ban |
| Alternative? | Yes – kratom products | Yes – kratom products |
Considering the Upcoming Federal Ban on Concentrated Kratom Alkaloids
Real Botanicals is offering a blowout sale this month up until the temporary federal ban takes effect in August. This unique opportunity allows you to stock up on Oxonol, 7-OH, and Pseudo by a manufacturer-direct vendor. Check out their Oxonol tablets, 7-OH tablets and shots, and Pseudo tablets while they’re still on the shelves.
Consider also their other products, like Acend High-MIT Attitude Adjustment tablets, Super Kratom kratom capsules, Mood Boost kratom and kava shots, or Mindless Mushrooms. These botanicals can benefit a variety of lifestyle routines and intentional moments of focus, social ease, relaxation, and pain relief. Real Botanicals formulates every product with scientific precision and in compliance with US regulations.
Choosing Kratom Products
If you’re in the market for alternatives to MGM15, consider Real Botanicals. In spite of the 7-OH ban, they’re not going anywhere, so stay tuned for new product releases. Consider their other kratom products, too, like Acend High-MIT Attitude Adjustment tablets, Super Kratom kratom capsules, Mood Boost kratom and kava shots, or Mindless Mushrooms. Every product is formulated with scientific precision and comply with US regulations.
You might also enjoy:”Where to Buy Affordable High-Quality Kratom Products” or “Pseudo vs. MGM15″ or “Oxonol vs. MIT“