7-hydroxymitragynine is not your typical opioid. It’s usually an opioid alternative to prescription opioids and serves the same use: Pain relief. More powerful than mitragynine, it’s found in tiny concentrations in the kratom leaf.
Also called 7-OH for short, it typically comes in the form of chewable tablets. Extract shots are another possibility. It depends on how you prefer to ingest it and how quickly you want it to take effect.
Regardless of the form you choose, dosing it is not as straightforward as one might think. 7-OH is part of the unregulated market of kratom. That makes it up to the user to not only choose an ethical vendor with strict quality control, but to educate themselves on taking 7-OH.
New users and anyone who wants the least amount to achieve effects can save money and avoid health risks by dosing 7-OH safely. Here, we find out how to choose a dosage of 7-OH that’s reasonable and responsible.
Creating 7-OH
The creation of 7-OH is often done through the following steps:
- Extraction: Extraction and isolation of mitragynine in large quantities with solvents such as ethanol. This creates a full-spectrum alkaloid extract.
- Isolation and conversion: In the kratom leaf, mitragynine is about 98% and 7-hydroxymitragynine is less than 2%. Since the former alkaloid is far more plentiful than the latter, the extracted mitragynine is converted into 7-hydroxymitragynine using a reactant and solvents.
- Purification and refinement: Contaminants and pollutants get left behind, so the remaining mixture is treated with solutions to neutralize it and isolate the 7-OH. Then, the crude product is purified; one method is alkaline column chromatography.
- Product formulation: To get to the final product, the 7-OH is then measured or weighed and combined with other ingredients such as binders or fillers, flavorings, or flow agents.
You can find the final product of 7-OH as:
Chewable tablets: If you only had one way to imagine 7-OH, it would likely be chewable tablets. It’s the most common form, usually has a bitter flavor, and takes effect immediately.
Shots: These are another extremely common way to find 7-OH. Shots are even more effective than chewable tablets, but not as long-lasting.
How Opioids Are Typically Dosed
An important fact to remember is that 7-OH is an opioid. It has much potential for addiction.
When doctors prescribe opioids, they tend to prescribe the lowest possible dose that will manage pain while minimizing risks. They consider the patient’s type of pain (acute or chronic), the opioid drug and its onset (immediate or extended-release). Also, they consider the patient’s circumstances, including age, organ function, and tolerance.
7-OH is an opioid and opioids generally have the risks of tolerance, addiction, and overdose. Their side effects include constipation, nausea, sedation, respiratory depression, and hormonal changes. Also, some 7-OH products may have higher concentrations per unit. That is why it is so important to properly dose 7-OH according to your needs and circumstances.
Dosing 7-OH
Every individual is different, so how do they know how much 7-OH to take? Here are a few tips:
Start low and slow: You always want to wait to gauge how you feel after taking the lowest possible dosage of 7-OH. Increase slowly by small increments rather than simply doubling your typical dosage.
Do not mix with other substances: 7-OH can be extremely dangerous and unpredictable when combined with other substances such as marijuana, alcohol, and other opioids.
Choose tablets or shots: Although you might find 7-OH in other forms, such as gummies, you usually have the option of tablets for immediate onset, long-lasting effects or immediate onset, short-lasting but more direct, strong pain relief. Acute pain sufferers may prefer the shots, while chronic pain sufferers may prefer tablets.
Use when necessary: Using 7-OH for recreational purposes greatly increases the risk of addiction and misuse.
Use on and off: It is best to take 7-OH for no more than a few days at a time to avoid developing tolerance and dependence. People with chronic pain may want to take it every day, but tend to choose kratom over 7-OH because it is not as potent and concentrated.
- Beginners: ¼ to ½ tablet or 1-2 mg; can slowly increase to 2.5-5mg.
- Typical dosage: 5-10 mg for tablets; 15 mg for shots.
- Frequency: No more than every 4 to 6 hours, depending on form.
- Daily limit: No more than 20 mg per day.
Consider Real Botanicals for Your 7-OH Needs

7-OH is unregulated, but that doesn’t mean it has to be unsafe. You can’t go wrong when you choose Real Botanicals 7-OH products, extracted and purified with patented ChromaPure technology. No other manufacturer can thoroughly eliminate contaminants and pollutants from the final product. Also, their 7-OH products are precisely dosed with 30 mg shots and their tablets are available in 10 mg, 20 mg, or 40 mg. Shop Real Botanicals 7-Hydro tablets and shots now.
You might be interested in reading “Round-up of the Best 7-OH Kratom Products.“
See Can “You get 7-OH from Home Grown Kratom?“

