People have different ways of getting into focus. When there’s a wellness or lifestyle supplement that can help you do that, even then, it’s a personal experience as to how it fits into your routine and which one you choose.
Each supplement is unique with multiple benefits besides enhancing focus. At a time when attention supplements abound, you have a variety of options.
Real Botanicals offers several products for doing that and more: Acend and Mindless Mushrooms are two of them. While one is a high-MIT kratom product, the other is a non-psilocybin microdosing product. Understand their differences in ingredients, use, and other aspects with a thorough comparison of each.
Formulating Focus in a Tablet
The typical method of extracting kratom alkaloids involves physical filters, silica, and solvents. Independent, third-party lab testing isn’t a guarantee of safety, but a measure of it. So even if a vendor’s kratom products have any kind of contaminants, there is some kind of threshold level they’ve deemed acceptable.
The problem is, it’s not acceptable to people who know that even a small presence of adulterants can and does alter the kratom products’ effects in a bad way and can be actively harmful to one’s health.
That’s why Good Manufacturing Practices are in demand for the unregulated market of botanicals, including kratom. GMP is equivalent to pharmaceutical, cosmetics, and food grade practices to make sure that anything you put on or in your body is safe.
Real Botanicals doesn’t just have a GMP-certified facility – they use pharmaceutical-grade, proprietary ChromaPure with RotaChrom CPC technology for the cleanest, most consistent kratom products like Acend. It starts with ethical sourcing of kratom, which is not something every vendor can say, either.
What’s more is they have their own lab for precision in formula creation, crucial for synthesizing legally-compliant Mindless Mushrooms, a microdosing tablet. You get the gamut of natural, semi-synthetic, and synthetic products you can use for energy, focus, and mood.
Acend
Have you wanted a caffeine alternative that’s also not the same as other kratom products? When you think of kratom, you likely imagine mitragynine-only or mitragynine-heavy. But these can vary in their alkaloid content and have inconsistencies between batches, not to mention they focus on the targeted effects of just one alkaloid.
Acend is neither of these. It is full-spectrum, much like Super Kratom and Mood Boost, but with some important differences. And unlike either, it’s best for people who are familiar with kratom – it is unique in its potency, which is why you should ‘upgrade’ to Acend instead of ‘downgrade’ to typical kratom products.
At lower doses, Acend boosts energy and focus and acts like a nootropic, besides emotional support, and works well for all-day effects first thing in the morning. At moderate doses, it won’t sedate, but will instead give physical comfort and mild pain relief for balance when you need greater ease to help you concentrate without distraction and get you through the day.
Mindless Mushrooms
Legal microdosing “mushrooms” products occupy two niches depending on what you choose: Recreational and creative or productive, mentally energetic, and attentive. They also have some differences in ingredients: The former may contain amanita or a synthetic formula, while the latter has a synthetic formula or one that includes functional mushrooms, like Lion’s Mane.
Mindless Mushrooms decidedly fits into the second niche. It’s the microdosing solution for people who want to use it for concentration, introspection, and mindfulness with ease — any activity that requires sustaining attention. That includes biohackers who want modern means of getting into the zone, also known as flow.
The tablet formula, like all of Real Botanicals’ products, contains no gluten, sugar, or animal by-products. And it uses pharmaceutical-grade microcrystalline cellulose as a binder, making it easier to absorb upon digestion with a consistency that goes down smoothly.
Using Brain Chemistry to Enhance Focus

To understand how Acend and Mindless Mushrooms work, we need to examine what they each do to the brain (and the body).
Full-spectrum kratom accounts for natural variations in alkaloid content and contains up to 40. Mitragynine makes up ⅔ of that content. What Acend does is create the most consistent, smoothest kratom experience by putting exact proportions of the following:
- Mitragynine, which makes up most of its effects
- Paynanthein, predominant after mitragynine and adds balance
- Speciogynine, a minor alkaloid for calm
- Speciocillatine, another minor alkaloid for calm
These pretty much run the gamut of kratom alkaloids. Acend’s effects come from this combination, all of which binds somewhat to mu-opioid receptors. MOR are located in the brain, spinal cord, and intestinal tract.
Those areas rule over pain processing, emotional regulation, sensory perception, and reward, and give insight to the gut-brain connection. In a nutshell: Acend gives a euphoric buzz and enhances attention and performance.
Mindless Mushrooms mirrors the brain chemistry of microdosing with psilocybin. The legal formula uses 4-hydroxy as its active ingredient. 4-hydroxy works along a similar vein as psilocybin’s active form, psilocin, by activating the serotonin 5HT2A receptor.
This subtype of the neurotransmitter serotonin is found mainly in the central nervous system (CNS) but also the gut and cardiovascular system. It has a role in higher cognitive thinking, decision-making, sensory perception, and reward, and Mindless Mushrooms’ effects include:
- Greater openness to ideas
- Cognitive enhancement
- Concentration
- Greater mindfulness
- Introspection
- Enhanced sensory perception
It’s the modern way to biohack productivity, especially for activities that require a lot of thinking, studying, problem-solving, or attention to detail.
Frequently Asked Questions
How should I take Acend?
You can read about the best scheduling protocol for kratom which includes full-spectrum kratom products like Acend.
How should I take Mindless Mushrooms?
Read about the Fadiman vs. Stamets Stack to learn about the best microdosing protocol.
Comparison Table
| Acend | Mindless Mushrooms | |
| Active ingredients | Mitragynine, paynanthein, speciogynine, speciocillatine | 4-hydroxy |
| Areas of brain affected | Brain, spinal cord, intestinal tract | Cerebral cortex, intestinal tract, cardiovascular system |
| Effects | Focus, emotional boost and support, energy | Focus, emotional uplift, mental energy |
| Side effects | Dizziness, nausea | Jitteriness, lack of appetite, nausea |
| Dose ceiling | ½ tablet per day | 1 tablet per day |
| Best for | Occasional and regular usage with 3-days-on, 2-days-off protocol; experienced users | Occasional usage or Stamets Stack protocol; anyone |
| Legal? | Yes | Yes |
| Alternative? | 7-OH and other concentrated kratom alkaloid alternative | Microdosing alternative to psilocybin mushrooms or products |
Choosing a Supplement for Focus
Acend and Mindless Mushrooms are wellness supplements that you can use for enhancing concentration. If your goal is to better your routine with other effects, don’t panic: They can also enhance physical and mental energy. Plus, Real Botanicals offers other products to support your lifestyle.
Also relevant: Can I Mix Kratom and Alcohol? Why You Shouldn’t and Oxonol vs. Acend: Supplements for Mental Clarity and More

