Posted by If you’ve read anything about concentrated kratom alkaloids, you’d learn that 7-OH and MGM15 are two of the top options. They stand for 7-hydroxymitragynine and dihydro-7-hydroxymitragynine, respectively, giving you an idea of how they differ on a chemical level. In order to truly understand their differences, though, you need to examine their effects on mind and body.
You should also be aware of the upcoming federal ban on 7-OH products, so keep that in mind.
How They’re Made
The concentrated extract of 7-OH is possible in one of two ways: Either by metabolizing mitragynine, or extracting the pure 7-hydroxymitragynine alkaloid from kratom leaves. Since the latter gives extremely low amounts, it’s the former we’ll refer to. This process involves chemical oxidation of mitragynine extract into 7-OH, after which it is incorporated with the ingredients to create the final products. 7-OH’s standard format is chewable tablets but sometimes as shots and other formats that may be unique to the vendor.
A rearrangement of mitragynine, or ultimately 7-hydroxymitragynine, through chemical means creates MGM15. The formal chemical name of the compound is dihydro-7-hydroxymitragynine (DH-7OH-MIT or DHM). It’s a more complex structure than 7-OH that offers more consistency, a clean onset, and direct, smooth character and a grounding rather than stimulating lift. MGM15 often comes as powders and tablets.
We can see that both 7-OH and MGM15 start with mitragynine, then use different chemical processes to create the final alkaloid concentrate from the original kratom extract. Whereas 7-OH is conversion of mitragynine, MGM15 takes it a step farther and converts the 7-OH.
Opioid Receptor Action and Effects
There are two ways concentrated kratom alkaloids can work on the three opioid receptors, by acting as:
- An agonist (binding action or affinity)
- An antagonist (blocking action)
Kratom alkaloids can bind to one or more opioid receptors, and they can also block the activation of certain opioid receptors. When they have both agonist and antagonist properties, we say they have mixed agonist profiles. Whereas single or dual-agonist profiles go one way, mixed-agonist profiles offer two-way effects where one action mitigates negative effects of the other.
Both 7-OH and MGM15 bind to mu-opioid receptors, which controls pain regulation and reward as well as the feeling of euphoria and is good for acute pain. However, 7-OH is also a competitive antagonist at delta- (pain and mood) and kappa-opioid receptors (pain, mood, stress, and reward or pleasure). These actions affect how 7-OH makes users feel a rush at the onset with peaks and valleys – not exactly smooth or consistent, but different.
MGM15 is like if someone thought to improve on 7-OH. It has a smoother onset and is more consistent and grounding-feeling as opposed to stimulating. It also binds to delta-opioid receptors, making it suitable for acute and chronic pain alike.
Scheduling Protocol, Side Effects and Risks
You need a scheduling or cycling protocol before taking 7-OH or MGM15. With kratom alkaloid products and especially concentrated ones, there’s a high risk of developing tolerance and dependence. They’re not meant for long-term, everyday use. Instead, you take one for some days and then two days off.
Looking for a scheduling protocol for 7-OH? Click here. It goes for MGM15, too.
The side effects of 7-OH and MGM15 are not the same. Both at high doses have a risk of Serotonin Syndrome, a potentially fatal condition.
Comparison Table
| MGM15 | 7-OH | |
| Targeted or broad-spectrum alkaloid profile? | Targeted (fast-acting, peak, narrow range of effects) | Targeted |
| Effects | Sedation, acute and chronic pain relief, mood enhancement | Sedation, chronic pain relief, mood enhancement |
| Side effects | Nausea, constipation, loss of appetite, dizziness, insomnia or drowsiness | Insomnia, anxiety, GI upset, drowsiness, respiratory depression |
| Strength with MIT as baseline | 3.5 times stronger than 7-OH and several times more than kratom | Several times more potent than kratom |
| Legal? | Not with upcoming federal ban | Not with upcoming federal ban |
| Alternative? | Yes – kratom products | Yes – kratom products |
Getting Ready for the Upcoming Federal Ban on 7-OH
It’s important to understand and be prepared for the federal ban that’s coming into effect on August 1st. Because of this, Real Botanicals is having a blowout sale. To get supply off the shelves, they’re giving a discount in addition to the free shipping with a minimum order. Even if you don’t normally stock up on 7-OH, now is the time to do so. They also have their proprietary enhanced kratom alkaloid blend, Oxonol, which contains MGM15 in addition to 7-OH and mitragynine.
Besides this, Real Botanicals has full-spectrum kratom products as an alternative to concentrated kratom alkaloids. Consider Acend High-MIT Attitude Adjustment tablets or the high dose of Super Kratom kratom capsules. These kratom products are considered natural and the law treats them differently from concentrated kratom alkaloids, including 7-OH and MGM15.
Real Botanicals for Premium Kratom Products
We at Kratom Experts want you to be up-to-date with all the latest information on kratom products. Real Botanicals’ small-but-varied product line has allowed them to offer natural full-spectrum kratom and other botanicals for mood, focus, energy, and relaxation. Stay in the loop for new releases.
You may also be interested in: “MGM15 vs. Oxonol” or “Pseudo vs. MGM15“