Posted by Kratom is one of the botanicals that has lately been getting a lot of media attention due to a recent announcement by the DEA to temporarily schedule 7-OH, MGM-15, MGM-16, and mitragynine pseudoindoxyl. These are alkaloids that occur naturally in kratom and are isolated using technologies like ChromaPure to make concentrated kratom extracts.
If this ban takes effect on August 5th, all products that contain these kratom alkaloids will be illegal. However, the DEA has yet to reveal the permissible threshold of each alkaloid in kratom products. Now, if you’ve been using kratom for a while, you have probably noticed that not all kratom products feel the same. One extract may give you a calm focus, another may feel deeply relaxing and longer-lasting than traditional powders.
The effects depend on the kratom alkaloids in the product and concentration. Before we look at the 7 main alkaloids used by manufacturers, it’s important to note that kratom contains more than 40 identified alkaloids, but only a handful have been studied and are commonly used in modern kratom extracts.
Summary Table of the Main Kratom Alkaloids
| Alkaloid | Natural occurrence in kratom | Commonly studied effects | Used in modern kratom extracts |
| Mitragynine | Major alkaloid | Focus, mood support, energy, and physical comfort | Acend |
| 7-hydroxymitragynine (7-OH) | Minor alkaloid | Potent analgesic and opioid-like effects | 7-OH products |
| MGM-15 | Derivative used in extracts | Deep relaxation, smooth focus, longer duration | Oxonol |
| MGM-16 | Derivative used in extracts | Limited public research | Experimental extracts |
| Mitragynine pseudoindoxyl | Metabolite or advanced alkaloid | Deep relaxation, grounded feeling, long duration | Pseudo |
| Speciogynine | Natural alkaloid | Muscle relaxation and full-spectrum support | Full-spectrum extracts |
| Paynantheine | Natural alkaloid | Relaxation and calming support | Full-spectrum extracts |
Let’s briefly look at the effects of products formulated with each of these kratom alkaloids.
Mitragynine
Mitragynine is a primary kratom alkaloid that is found in larger quantities than all other six alkaloids. Most of the kratom products that will be legal after the federal ban takes effect contain this alkaloid as the main ingredient.
Think of it as the dominant kratom alkaloid. Commonly reported effects include mood support, increased motivation, mild stimulation at lower doses, and relaxation at higher doses.
7-Hydroxymitragynine
Also referred to as 7-OH, 7-hydroxymitragynine is present in much smaller amounts than mitragynine. But despite being found in small quantities, it’s the most potent naturally occurring kratom alkaloid.
It binds strongly to opioid receptors, resulting in stronger, longer-lasting effects. Many people describe its effects as more pronounced and longer-lasting than traditional leaf kratom.
MGM-15
MGM-15 is a kratom-derived compound used in some advanced extract formulations like Oxonol. This is one of the compounds DEA intends to schedule, so Oxonol and other products containing it will not be available after August 5th.
It is generally associated with enhanced potency and a more concentrated effect profile, which is why products containing MGM-15 are usually intended for experienced kratom users.
MGM-16
MGM-16 is another kratom-derived compound used in specialized extract products. This is another compound that the DEA plans to schedule due to its ability to deliver stronger effects than standard leaf products.
Research on MGM-16 remains is limited, and most discussions focus on its use in concentrated kratom extracts rather than its occurrence as a major natural alkaloid in the plant.
Mitragynine pseudoindoxyl
Mitragynine pseudoindoxyl is a metabolite and derivative of mitragynine that has attracted significant scientific interest. Research suggests it may interact with opioid receptors differently from both mitragynine and 7-OH. DEA is closely monitoring its use on kratom products and intends to schedule it alongside MGM-15, 7-OH, and MGM-16.
This alkaloid is mostly used in new kratom extracts like Pseudo tablets. Most of the customers we interacted with say this extract delivers a stronger relaxing effect and has a different overall character compared with traditional kratom products.
Speciogynine
Speciogynine is arguably one of the least talked about kratom alkaloids, but surprisingly, it’s a major secondary alkaloid. It’s considered less potent than mitragynine and 7-OH, but its ability to enhance the plant’s relaxing properties cannot be overlooked.
Some research findings we found suggest that speciogynine plays a supporting role through muscle-relaxant and smooth muscle effects, which can influence how a full-spectrum kratom extract feels.
Paynantheine
Paynantheine is another secondary kratom alkaloid that is found in high quantities after mitragynine. Research shows it is a smooth muscle relaxant and may contribute to the calming, body-focused effects that many users notice with certain kratom strains and extracts.
Most of the full-spectrum kratom products often contain paynantheine alongside the other naturally occurring alkaloids.
What’s Next After the Federal Ban?
On 1st July 2026, DEA filed two notices of intent to temporarily ban kratom products that contain 7-OH, MGM-15, MGM-16, and Mitragynine pseudoindoxyl. This means that a large number of kratom extracts won’t be available if the ban is implemented on August 5th.
Before then, you can still legally buy kratom extracts that contain these compounds, such as Oxonol and Pseudo, before 5th August.
Also, Acend, one of the new kratom extracts from Real Botanicals, will not be affected by the ban. The brand will soon launch new kratom extracts that will be fully compliant with the DEA directive. We will share more details soon.
Use code WTFDEA to get 20% off on Oxonol, Pseudo, Acend, and other 7-OH products.