In the world of botanicals, 7-OH is often available at the same time as kratom. However, although 7-OH is a concentrated kratom alkaloid, neither the effects nor the law regarding it are the same. Whether it’s side effects like the high risk of tolerance, dependence, and abuse, respiratory depression, GI upset, or ever-changing regulations, 7-OH has become controversial.
The potent kratom alkaloid products have had a relatively brief but powerful run, although they’re still around. These days, people are looking for alternatives. What they want are fewer side effects and greater legality.
Fortunately, there are products that offer both. Here’s a review of 5 of the ideal 7-OH alternatives.
What Makes the Best 7-OH Alternative?
A 7-OH alternative, even the best one, is not meant to be “almost the same” as 7-OH. It’s unique. What’s different is:
- It has fewer side effects when compared to those of 7-OH;
- It is often allowed where 7-OH is banned; and
- It offers pain relief, mood support, and sometimes also energy or focus
All of these features must be true at once to not only be one possible 7-OH alternative, but one of the leading, formidable alternatives that can go toe-to-toe and not only serve similar, but include greater niches of people who enjoy their unique effects.
Oxonol
You might think that Oxonol sounds like just another kratom alkaloid botanical available through several vendors, but it’s not. It’s a proprietary 7-OH alternative by Real Botanicals that’s an enhanced kratom alkaloid blend. It includes 7-OH, mitragynine, and MGM-15, along with 2 other kratom alkaloids.

Compared to 7-OH chewable tablets, which are often flavorless, it has many positive differences. They are strawberry flavored, offer full-body relief and general support with a fast onset and smooth effects over targeted alkaloid effects, and they’re compliant across the U.S. Choose from 30 or 60 mg tablets you can evenly and easily split into more manageable halves for relief with re-dosing but not overdoing it.
Pseudo
Pseudo is the short name for mitragynine pseudoindoxyl. It’s a semi-synthetic compound that’s a rearrangement of 7-hydroxymitragynine (7-OH), a metabolite of kratom as well as a primary alkaloid present in tiny amounts within kratom leaves. 7-OH can convert to Pseudo in human plasma, and in this sense, being an active metabolite, it has different and even more profound effects for pain relief.

This rearrangement offers several important differences that make it a strong alternative. First, it’s still a potent mu-opioid receptor agonist (it binds strongly); in fact, even more so than 7-OH. But it manages to induce fewer side effects because it’s also a delta-opioid receptor antagonist, meaning it binds to it without activating it. 7-OH, on the other hand, is a competitive delta- and kappa-opioid receptor antagonist.
Users report that Pseudo has a heavy, grounding feeling. It lasts all day, eliminating the need for redosing. Pseudo is available in chewable tablets and sometimes in concentrated shots.
MGM-15
A semi-synthetic alkaloid from kratom, MGM-15, might make more sense as its chemical name, dihydro-7-hydroxymitragynine. In other words, it’s a lab-created derivative of 7-OH. It’s an agonist at mu- and delta-opioid receptors, making it potent for pain relief and mood support as well as long-lasting, even more so than 7-OH. Also, it could be legal where 7-OH is not.
MGM15 comes in powder form with various potency percentages (up to 99%) as well as chewable tablets.
Kratom
At the milder end of 7-OH alternatives is kratom, which is often available as MIT – standing for mitragynine, the primary and dominant alkaloid in kratom. But I’ll do you one better: Some vendors offer full-spectrum kratom, which provides up to 40 different alkaloids in direct extraction for a more wholesome, potent experience.
Since kratom is dose-dependent, you can tailor effects for energy and focus at low doses, balance and mild pain relief at moderate doses, and sedation and moderate pain relief at high doses. On the other hand, you can also experiment with different kratom strains for focus, energy, and/or mood support with nuanced effects.
Kratom is available as powder, capsules, and even edibles.
Kratom + Kava
If you’re looking for occasional relief and don’t want to risk 7-OH tolerance and dependence, consider kratom and kava. This winning combination is popular as an alcohol alternative and stress reliever. While the kava is for anxiety and stress and so offers relaxation, the kratom does offer a measure of pain relief. Together, they encourage calm and sociability.
Kratom and kava together is available as shots, with varying proportions depending on vendor and availability.
7-OH Alternatives That Make Sense
Whether you’re interested in Pseudo, their proprietary Oxonol, kratom capsules, or kratom and kava shots, Real Botanicals has all three. You can’t go wrong with 7-OH alternatives with options that range from milder to stronger effects, all with greater legality and fewer risks than 7-OH. Their proprietary ChromaPure is an advanced technology that extracts full-spectrum kratom alkaloids and eliminates impurities at the same time, while they formulate allergy-friendly 7-OH alternatives for more targeted results.
Also check out: “5 of the Best 7-OH Vendors.”
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